Digital Health
Schliess, F., Affini Dicenzo, T., Gaus, N., Bourez, J.-M., Stegbauer, C., Szecsenyi, J., Jacobsen, M., Müller-Wieland, D., Kulzer, B., Heinemann, L.
The German fast track towards reimbursement of digital health applications (DiGA): Opportunities and challenges for manufacturers, healthcare providers and people with diabetes.
J. Diabetes Sci. Technol. 18(2):470-476, 2024
​
Han, S., Huang, J., Foppiano, F., Prehn, C., Adamski, J., Suhre, K., Li, Y., Matullo, G., Schliess, F., Gieger, C., Peters, A., Wang-Sattler, R.
TIGER: Technical variation elimination for metabolomics data using ensemble learning architecture.
Brief. Bioinform. 23(2):bbab535, 2022
​
Schliess, F.
Automated Insulin Delivery für Menschen mit Typ 2 Diabetes? Die pan-europäische CLOSE Initiative (in German).
Diatec weekly, January 14, 2022.
​
Huang, J., Covic, C., Huth, C., Rommel, M., Adam, J., Zukunft, S., Prehn, C., Wang, L., Nano, J., Scheerer, M.F., Neschen, S., Kastenmüller, G., Gieger, C., Laxy, M., Schliess, F., Adamski, J., Suhre, K., Hrabe de Angelis, M., Peters, A. Wang-Sattler, R.
Validation of candidate phospholipid biomarkers of chronic kidney disease in hyperglycemic individuals and their organ-specific exploration in leptin receptor-deficient db/db mouse.
Metabolites 11, 89, 2021
​
Jones, A., Bardram, J.E., Bækgaard, P., Cramer-Petersen, C.L., Skinner, T., Vrangbæk, K., Starr, L., Nørgaard, K., Lind, N., Bechmann Christensen, M., Glümer, C., Wang-Sattler, R., Laxy, M., Brander, E., Heinemann, L., Heise, T., Schliess, F., Ladewig, K., Kownatka, D.
Integrated personalized diabetes management goes Europe: A multi-disciplinary approach to innovating type 2 diabetes care in Europe.
Primary Care Diabetes 15, 360-364, 2021.
Schliess, F.
Proving the effectiveness of digital health technologies.
Open Access Government ISSN 2586-3917. October 6, 2021.
​
Schliess, F.
Can Remote Decentralised Clinical Trials enhance clinical research?
Profil Blog June 2, 2021.
​
Schliess, F.
What does the European Medical Devices Regulation 2017/745 (MDR) say about clinical trials?
Open Access Government ISSN 2516-3817, June 21, 2021.
​
Stegbauer, C., Falivena, C., Moreno, A., Hentschel, A., Rosenmöller, M., Heise, T., Szecsenyi, J., Schliess, F.
Costs and its drivers for diabetes mellitus type 2 patients in France and Germany: A systematic review of economic studies.
BMC Health. Serv. Res. 20, 1043, 2020
​
Huang, J., Huth, C., Covic, M., Troll, M., Adam, J., Zukunft, S., Prehn, C., Wang, L., Nano, J., Scheerer, M.F., Neschen, S., Kastenmüller, G., Suhre, K., Laxy, M., Schliess, F., Gieger, C., Adamski, J., Hrabe de Angelis, M., Peters, A., Wang-Sattler, R.
Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes.
Diabetes 69, 2756–2765, 2020.
​
Gruchala, A., Cypryk, K., Schliess, F., Bobeff, K., Heise, T., Gurdala, M., Szadkowska, A., Mianowska, B.
Pains and needs of patients with type 2 diabetes as targets for novel technologies.
Clinical Diabetology 9, 400-410, 2020.
​
Affini-Dicenzo,T., Schliess, F.
Bridging the gap between clinical trials and clinical care.
Open Access Government Technology eBook,.September 28,2020.
​
Schliess, F.
Continuous real-world monitoring of cardiorespiratory health.
Open Access Government Special Health and Social Care Report, September 2, 2020
​
Schliess, F.
Digital twins: Are they game-changers in clinical research and clinical care?
Open Access Government ISSN 2516-3817, August 26, 2020.
​
Schliess, F.
A vision on remote decentralised clinical trials.
Open Access Government ISSN 2516-3817. June 17, 2020.
​
Schliess, F.
Think tank highlights CROs key role in optimising innovation pathways.
Open Access Government ISSN 2516-3817. March 26, 2020.
​
Schliess, F.
Digital Diabetes: Better trials, better drugs, better care.
Profil Blog. January 29, 2019
​
Schliess, F.
Clinical contract research: Building the digital bridge between clinical research and clinical care.
Open Access Government. ISSN 2516-3817. August 23, 2019
​
Schliess, F., Heise, T., Benesch, C., Mianowska, B., Stegbauer, C., Broge, B., Gillard, P., Binkley, G., Crône, V., Carlier, S., Delval, C., Petkov, A., Beck, J.P., Lodwig, V., Gurdala, M., Szecsenyi, J., Rosenmöller, M., Cypryk, K., Mathieu, C., Renard, E., Heinemann, L. (2019).
Artificial pancreas systems for people with type 2 diabetes: conception and design of the European CLOSE project.
J. Diabetes Sci. Technol. 13(2), 261-267, 2019.
​
Schliess, F.
Do-it-yourself artificial pancreas systems (DIY APS).
Profil Blog. September 5, 2018
Drug Development
Meier, J.J., Menge, B.A., Schenker, N., Erdmann, S., Kahle-Stephan, M., Schliess, F., Kapitza, C., Nauck, M.A.
Effects of sequential treatment with lixisenatide, insulin glargine, or their combination on meal-related glycaemic excursions, insulin and glucagon secretion, and gastric emptying in patients with type 2 diabetes.
Diabetes Obes. Metab. 22, 599-611, 2020.
Schliess, F.
A life- and disease course approach to health protection and chronic care.
Open Access Government. ISSN 2516:3817. April 12, 2019.
​
Meier, J.J., Schenker, N., Kahle, M., Schliess, F., Kapitza, C. and Menge, B.A.
Impact of insulin glargine and lixisenatide on β-cell function in patients with type 2 diabetes mellitus: A randomized open-label study.
Diabetes Obes. Metab. 19, 1625-1629, 2017.
Schliess, F.
Glucose clamps: 2 steps towards hepatic and peripheral insulin sensitivity.
Profil Blog. August 9, 2017
​
Schliess, F.
Glucose clamps: 2 steps towards insulin sensitivity adjusted for glucose effectiveness.
Profil Blog. March 16, 2017.
​
Muscelli, E., Astiarraga, E., Barsotti, E., Mari, A., Schliess, F., Nosek, L., Heise, T., Broedl, U.C., Woerle, H.J. and Ferrannini, E. (2016).
Metabolic consequences of acute and chronic empagliflozin administration in treatment-naive and metformin pretreated patients with type 2 diabetes.
Diabetologia 59, 700-708, 2016, 2016.
​
Marquard, J., Stirban, A., Schliess, F., Sievers, F., Welters, A., Otter, S., Fischer, A., Wnendt, S., Meissner, T., Heise, T., and Lammert, E.
Effects of dextromethorphan as add-on to sitagliptin on blood glucose and serum insulin concentrations in individuals with type 2 diabetes mellitus: A randomized, placebo-controlled, double-blinded, multiple crossover, single-dose clinical trial.
Diabetes Obes. Metab. 18, 100-103, 2016.
​
Schliess, F.
Liver first? Part III: Medical needs and clinical trials in NAFL and NASH.
Profil Blog. December 9, 2016.
​
Marquard, J., Otter, S., Welters, A., Stirban, A., Eglinger, J., Herebian, D., Kletke, O., Klemen, M.S., Stoze, A., Wnendt, S., Piemonti, L., Köhler, M., Ferrer, J., Thorens, B., Schliess, F., Rupnik, M.S., Heise, T., Berggren, P.O., Klöcker, N., Meissner, T., Mayatepek, E., Eberhard, D., Kragl, M. and Lammert, E.
Characterization of pancreatic N-Methyl-D-Aspartate receptors as possible drug targets for diabetes treatment.
Nature Medicine 21, 363-372, 2015.
​
Boronikolos, G.C., Menge, B.A., Schenker, N., Breuer, T.G., Ötte, J.M., Heckermann, S., Schliess, F. and Meier, J.J. (2015).
Upper gastrointestinal motility and symptoms in individuals with diabetes, prediabetes and normal glucose tolerance.
Diabetologia 58, 1175-1182, 2015. ​
Schliess, F. and Heise, T.
Insulin glulisine: Preclinical hallmarks and clinical efficacy.
Therapy 6, 209-229, 2009
Translational Research
Meier, J.J., Menge, B.A., Schenker, N., Erdmann, S., Kahle-Stephan, M., Schliess, F., Kapitza, C., Nauck, M.A.
Effects of sequential treatment with lixisenatide, insulin glargine, or their combination on meal-related glycaemic excursions, insulin and glucagon secretion, and gastric emptying in patients with type 2 diabetes.
Diabetes Obes. Metab. 22, 599-611, 2020.
​
Schliess, F.
NAFLD/NASH: A ticking bomb not yet defused.
Profil Blog. April 25, 2019
​
Schliess, F.
A life- and disease course approach to health protection and chronic care.
Open Access Government. ISSN 2516:3817, April 12, 2019.
​
Schliess, F.
Diabetes: A paradigm case for rewarding innovation in value-based healthcare.
Open Access Government. ISSN 2516-3817, June 19, 2018.
Schliess, F.
Preface: Center for Digital Technology and Management (CDTM) Digital Innovation in Diabetes Care Trend Report 2016.
Schliess, F.
Liver first? Part II: NASH and NAFLD pathogenetic traits.
Profil Blog. December 1, 2016.
​
Schliess, F.
Liver first? Part I: The liver in diabetes and cardiovascular disease.
Profil Blog. Juli 20, 2016.
​
Marquard, J., Otter, S., Welters, A., Stirban, A., Eglinger, J., Herebian, D., Kletke, O., Klemen, M.S., Stoze, A., Wnendt, S., Piemonti, L., Köhler, M., Ferrer, J., Thorens, B., Schliess, F., Rupnik, M.S., Heise, T., Berggren, P.O., Klöcker, N., Meissner, T., Mayatepek, E., Eberhard, D., Kragl, M. and Lammert, E.
Characterization of pancreatic N-Methyl-D-Aspartate receptors as possible drug targets for diabetes treatment.
Nature Medicine 21, 363-372, 2015.
Schliess, F.
Open innovation: What’s going on in the healthcare sector?
Profil Blog. October 26, 2015.
Schliess, F.
Diabetic and hepatic encephalopathy: Similarities, synergies and differences.
Profil Blog. July 30., 2015.
​
Schliess, F.
For healthy living and active ageing: Profil has joined EIT Health.
Profil Blog. April 7, 2015.
​
Schliess, F., Hoehme, S., Henkel, S.G., Ghallab, A., Driesch, D., Böttger, J., Guthke, R., Pfaff, M., Hengstler, J.G., Gebhardt, R., Häussinger, D., Drasdo, D. and Zellmer, S.
Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration.
Hepatology 60, 2040-2051, 2014.
​
Karababa, A., Görg, B., Schliess, F. and Häussinger, D.
O-Glc-NAcylation as a novel ammonia-induced post-translational protein modification in cultured astrocytes.
Metab. Brain Dis. 29, 975-982, 2014
​
Hoffmann, L., Brauers, G., Gehrmann, T., Häussinger, D., Mayatepek, E., Schliess, F. and Schwahn, B.C. Osmotic regulation of hepatic betaine metabolism.
Am. J. Physiol. Gastrointest. Liver Physiol. 304, G835-G846, 2013.
Kruczek, C., Görg, B., Keitel, V., Bidmon, H.J., Schliess, F. and Häussinger, D.
Ammonia increases nitric oxide, free Zn2+ and metallothionein mRNA expression in cultured rat astrocytes.
Biol. Chem. 392, 1155-1165, 2011.
​
Schliess, F., Görg, B. and Häussinger, D.
RNA oxidation and zinc in hepatic encephalopathy and hyperammonemia.
Metab. Brain Dis. 24, 119-134, 2009.
Kruczek, C., Görg, B., Keitel, V., Pirev, E., Kröncke, K.D., Schliess, F. and Häussinger, D.
Hypoosmotic swelling affects zinc homeostasis in cultured rat astrocytes.
GLIA 57, 79-92, 2009.
Häussinger, D. and Schliess, F.
Pathogenetic mechanisms of hepatic encephalopathy.
Gut 57, 1156-1165, 2008.
Mannack, G., Graf, D., Donner, M.M., Richter, L., Görg, B., vom Dahl, S., Häussinger, D., and Schliess, F.
Taurolithocholic acid-3 sulfate impairs insulin signaling in cultured rat hepatocytes and perfused rat liver.
Cell Physiol. Biochem. 21, 137-150, 2008.
Görg,B., Qvartskhava, N., Keitel, V., Bidmon, H.J., Selbach, O., Schliess, F. and Häussinger, D.
Ammonia induces RNA oxidation in cultured rat astrocytes and brain in vivo.
Hepatology 48, 567-579, 2008.
Schliess, F., Reinehr, R. and Häussinger,
Osmosensing and signaling in the regulation of mammalian cell function.
FEBS J. 274, 5799-5803, 2007.
​
Häussinger D. and Schliess, F.
Glutamine metabolism and signaling in the liver.
Front. Biosci. 12, 371-391, 2007.
​
Schliess, F. and Häussinger, D.
Osmosensing by integrins in rat liver.
Meth. Enzymol. 428, 129-144, 2007.
​
Schäfer, C., Gehrmann, T., Richter, L., Keitel, V., Köhrer, K., Häussinger, D. and Schliess, F.
Modulation of gene expression profiles by hyperosmolarity and insulin.
Cell Physiol. Biochem. 20, 369-386, 2007.
Schäfer, C., Hoffmann, L., Heldt, K., Lornejad-Schäfer, M.R., Brauers, G., Gehrmann, T., Garrow, T.A., Häussinger, D., Mayatepek, E., Schwahn, B. and Schliess, F.
Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells.
Am. J. Physiol Gastrointest. Liver Physiol. 292, G1089-G1098, 2007.
​
Görg, B., Qvartskhava, N., Voss, P., Grune, T. Häussinger, D., Schliess, F.
Inhibition of mammalian glutamine synthetase by tyrosine nitration.
FEBS Lett. 581, 84-90, 2007.
Häberle, J., Görg, B., Toutain, A., Rutsch, F., Benoist, J.F., Gelot, A., Suc, A.L., Koch, H.G., Schliess, F. and Häussinger, D
Inborn error of amino acid synthesis: human glutamine synthetase deficiency.
J. Inherit. Metab. Dis. 29, 352-358, 2006.
Schliess, F., Görg, B., Reinehr, R., Bidmon, H.J. and Häussinger, D.
Osmotic and oxidative stress in hepatic encephalopathy.
In „Hepatic encephalopathy and nitrogen metabolism“. Editors: D. Häussinger, G. Kircheis, F. Schliess.
Springer, Dordrecht, The Netherlands, p. 20-42.
​
Schliess, F., Görg, B. and Häussinger, D.
Pathogenetic interplay between osmotic and oxidative stress: The hepatic encephalopathy paradigm.
Biol. Chem. 387, 1363-1370, 2006.
​
Häussinger, D., Reinehr, R.M. and Schliess, F.
The hepatocyte integrin system and cell volume sensing.
Acta Physiol. 187, 249-255, 2006.
Schliess, F., Richter, L., vom Dahl, S. and Häussinger, D.
Cell hydration and mTOR-dependend signaling.
Acta Physiol. 187, 223-229, 2006.
​
Häussinger, D., Görg, B., Reinehr, R.M. and Schliess, F.
Protein tyrosine nitration in hyperammonemia and hepatic encephalopathy.
Metab. Brain. Dis. 20, 285-294, 2005.
​
Schliess, F. and Häussinger, D.
The cellular hydration state: role in apoptosis and proliferation.
Signal Transduction 6, 297-302, 2005.
Lornejad Schäfer, M.R., Schäfer, C., Richter, L., Grune, T., Häussinger, D. and Schliess, F.
Osmotic regulation of MG-132-induced MAP-kinase phosphatase MKP-1 expression in H4IIE rat hepatoma cells.
Cell. Physiol. Biochem. 16, 193-206, 2005.
Lornejad-Schäfer, M.R., Albrecht, U. Poppeck, D., Gehrmann, T., Grune, T., Bode, J.G., Häussinger, D. and Schliess, F.
Osmotic regulation of STAT3 stability in H4IIE rat hepatoma cells.
FEBS Lett. 579, 5791-5707, 2005.
Häberle, J., Görg, B., Rutsch, F., Schmidt, E., Toutain, A., Benoist, J.F., Gelot, A., Suc, A.L., Höhne, W., Schliess, F., Häussinger, D. and Koch, H.G.
Congenital glutamine deficiency with glutamine synthetase mutations.
N. Engl. J. Med. 353, 1926-1933, 2005.
​
Häussinger, D., Kubitz, R., Reinehr, R.M., Bode, J.G. and Schliess, F.
Molecular aspects of medicine: From experimental to clinical hepatology.
Mol. Aspects Med. 25, 221-360, 2004.
​
Schliess, F., Foster, N., Görg, B., Reinehr, R. and Häussinger, D.
Hypoosmotic swelling increases protein tyrosine nitration in cultured rat astrocytes.
GLIA 47, 21-29, 2004.
​
Schliess, F., Reissmann, R., Reinehr, R., vom Dahl, S. and Häussinger, D.
Involvement of integrins and Src in insulin signaling towards autophagic proteolysis in rat liver.
J. Biol. Chem. 279, 21294-21301, 2004.
​
Häussinger, D., Kurz, A.K., Wettstein, M., Graf, D., vom Dahl, S. and Schliess, F.
Involvement of integrins and Src in tauroursodesoxycholate and swelling-induced choleresis. Gastroenterology 124, 1476-1487, 2003.
Schliess, F. and Häussinger, D.
Cell volume and insulin signalling.
Int. Rev. Cytol. 225, 187-228, 2003.
​
Schliess,F. and Häussinger D.
The cellular hydration state: a critical determinant for cell death and cytoprotection.
Biol. Chem. 383, 577-583, 2002.
​
Schliess, F. and Häussinger, D.
Hepatic encephalopathy and nitric oxide.
J. Hepatol. 34, 610-612, 2001.
​
Schliess, F. and Stoffel, W.
Evolution of the myelin integral membrane proteins of the central nervous system.
Biol. Chem. Hoppe-Seyler 372, 865-874, 1991.
​
​
​