Digital Health
Schliess, F., Affini Dicenzo, T., Gaus, N., Bourez, J.-M., Stegbauer, C., Szecsenyi, J., Jacobsen, M., Müller-Wieland, D., Kulzer, B., Heinemann, L.
The German fast track towards reimbursement of digital health applications (DiGA): Opportunities and challenges for manufacturers, healthcare providers and people with diabetes.
J. Diabetes Sci. Technol. 18(2):470-476, 2024
Han, S., Huang, J., Foppiano, F., Prehn, C., Adamski, J., Suhre, K., Li, Y., Matullo, G., Schliess, F., Gieger, C., Peters, A., Wang-Sattler, R.
TIGER: Technical variation elimination for metabolomics data using ensemble learning architecture.
Brief. Bioinform. 23(2):bbab535, 2022
Schliess, F.
Automated Insulin Delivery für Menschen mit Typ 2 Diabetes? Die pan-europäische CLOSE Initiative (in German).
Diatec weekly, January 14, 2022.
Huang, J., Covic, C., Huth, C., Rommel, M., Adam, J., Zukunft, S., Prehn, C., Wang, L., Nano, J., Scheerer, M.F., Neschen, S., Kastenmüller, G., Gieger, C., Laxy, M., Schliess, F., Adamski, J., Suhre, K., Hrabe de Angelis, M., Peters, A. Wang-Sattler, R.
Validation of candidate phospholipid biomarkers of chronic kidney disease in hyperglycemic individuals and their organ-specific exploration in leptin receptor-deficient db/db mouse.
Metabolites 11, 89, 2021
Jones, A., Bardram, J.E., Bækgaard, P., Cramer-Petersen, C.L., Skinner, T., Vrangbæk, K., Starr, L., Nørgaard, K., Lind, N., Bechmann Christensen, M., Glümer, C., Wang-Sattler, R., Laxy, M., Brander, E., Heinemann, L., Heise, T., Schliess, F., Ladewig, K., Kownatka, D.
Integrated personalized diabetes management goes Europe: A multi-disciplinary approach to innovating type 2 diabetes care in Europe.
Primary Care Diabetes 15, 360-364, 2021.
Schliess, F.
Proving the effectiveness of digital health technologies.
Open Access Government ISSN 2586-3917. October 6, 2021.
Schliess, F.
Can Remote Decentralised Clinical Trials enhance clinical research?
Profil Blog June 2, 2021.
Schliess, F.
What does the European Medical Devices Regulation 2017/745 (MDR) say about clinical trials?
Open Access Government ISSN 2516-3817, June 21, 2021.
Stegbauer, C., Falivena, C., Moreno, A., Hentschel, A., Rosenmöller, M., Heise, T., Szecsenyi, J., Schliess, F.
Costs and its drivers for diabetes mellitus type 2 patients in France and Germany: A systematic review of economic studies.
BMC Health. Serv. Res. 20, 1043, 2020
Huang, J., Huth, C., Covic, M., Troll, M., Adam, J., Zukunft, S., Prehn, C., Wang, L., Nano, J., Scheerer, M.F., Neschen, S., Kastenmüller, G., Suhre, K., Laxy, M., Schliess, F., Gieger, C., Adamski, J., Hrabe de Angelis, M., Peters, A., Wang-Sattler, R.
Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes.
Diabetes 69, 2756–2765, 2020.
Gruchala, A., Cypryk, K., Schliess, F., Bobeff, K., Heise, T., Gurdala, M., Szadkowska, A., Mianowska, B.
Pains and needs of patients with type 2 diabetes as targets for novel technologies.
Clinical Diabetology 9, 400-410, 2020.
Affini-Dicenzo,T., Schliess, F.
Bridging the gap between clinical trials and clinical care.
Open Access Government Technology eBook,.September 28,2020.
Schliess, F.
Continuous real-world monitoring of cardiorespiratory health.
Open Access Government Special Health and Social Care Report, September 2, 2020
Schliess, F.
Digital twins: Are they game-changers in clinical research and clinical care?
Open Access Government ISSN 2516-3817, August 26, 2020.
Schliess, F.
A vision on remote decentralised clinical trials.
Open Access Government ISSN 2516-3817. June 17, 2020.
Schliess, F.
Think tank highlights CROs key role in optimising innovation pathways.
Open Access Government ISSN 2516-3817. March 26, 2020.
Schliess, F.
Digital Diabetes: Better trials, better drugs, better care.
Profil Blog. January 29, 2019
Schliess, F.
Clinical contract research: Building the digital bridge between clinical research and clinical care.
Open Access Government. ISSN 2516-3817. August 23, 2019
Schliess, F., Heise, T., Benesch, C., Mianowska, B., Stegbauer, C., Broge, B., Gillard, P., Binkley, G., Crône, V., Carlier, S., Delval, C., Petkov, A., Beck, J.P., Lodwig, V., Gurdala, M., Szecsenyi, J., Rosenmöller, M., Cypryk, K., Mathieu, C., Renard, E., Heinemann, L. (2019).
Artificial pancreas systems for people with type 2 diabetes: conception and design of the European CLOSE project.
J. Diabetes Sci. Technol. 13(2), 261-267, 2019.
Schliess, F.
Do-it-yourself artificial pancreas systems (DIY APS).
Profil Blog. September 5, 2018
Drug Development
Meier, J.J., Menge, B.A., Schenker, N., Erdmann, S., Kahle-Stephan, M., Schliess, F., Kapitza, C., Nauck, M.A.
Effects of sequential treatment with lixisenatide, insulin glargine, or their combination on meal-related glycaemic excursions, insulin and glucagon secretion, and gastric emptying in patients with type 2 diabetes.
Diabetes Obes. Metab. 22, 599-611, 2020.
Schliess, F.
A life- and disease course approach to health protection and chronic care.
Open Access Government. ISSN 2516:3817. April 12, 2019.
Meier, J.J., Schenker, N., Kahle, M., Schliess, F., Kapitza, C. and Menge, B.A.
Impact of insulin glargine and lixisenatide on β-cell function in patients with type 2 diabetes mellitus: A randomized open-label study.
Diabetes Obes. Metab. 19, 1625-1629, 2017.
Schliess, F.
Glucose clamps: 2 steps towards hepatic and peripheral insulin sensitivity.
Profil Blog. August 9, 2017
Schliess, F.
Glucose clamps: 2 steps towards insulin sensitivity adjusted for glucose effectiveness.
Profil Blog. March 16, 2017.
Muscelli, E., Astiarraga, E., Barsotti, E., Mari, A., Schliess, F., Nosek, L., Heise, T., Broedl, U.C., Woerle, H.J. and Ferrannini, E. (2016).
Metabolic consequences of acute and chronic empagliflozin administration in treatment-naive and metformin pretreated patients with type 2 diabetes.
Diabetologia 59, 700-708, 2016, 2016.
Marquard, J., Stirban, A., Schliess, F., Sievers, F., Welters, A., Otter, S., Fischer, A., Wnendt, S., Meissner, T., Heise, T., and Lammert, E.
Effects of dextromethorphan as add-on to sitagliptin on blood glucose and serum insulin concentrations in individuals with type 2 diabetes mellitus: A randomized, placebo-controlled, double-blinded, multiple crossover, single-dose clinical trial.
Diabetes Obes. Metab. 18, 100-103, 2016.
Schliess, F.
Liver first? Part III: Medical needs and clinical trials in NAFL and NASH.
Profil Blog. December 9, 2016.
Marquard, J., Otter, S., Welters, A., Stirban, A., Eglinger, J., Herebian, D., Kletke, O., Klemen, M.S., Stoze, A., Wnendt, S., Piemonti, L., Köhler, M., Ferrer, J., Thorens, B., Schliess, F., Rupnik, M.S., Heise, T., Berggren, P.O., Klöcker, N., Meissner, T., Mayatepek, E., Eberhard, D., Kragl, M. and Lammert, E.
Characterization of pancreatic N-Methyl-D-Aspartate receptors as possible drug targets for diabetes treatment.
Nature Medicine 21, 363-372, 2015.
Boronikolos, G.C., Menge, B.A., Schenker, N., Breuer, T.G., Ötte, J.M., Heckermann, S., Schliess, F. and Meier, J.J. (2015).
Upper gastrointestinal motility and symptoms in individuals with diabetes, prediabetes and normal glucose tolerance.
Diabetologia 58, 1175-1182, 2015.
Schliess, F. and Heise, T.
Insulin glulisine: Preclinical hallmarks and clinical efficacy.
Therapy 6, 209-229, 2009
Translational Research
Meier, J.J., Menge, B.A., Schenker, N., Erdmann, S., Kahle-Stephan, M., Schliess, F., Kapitza, C., Nauck, M.A.
Effects of sequential treatment with lixisenatide, insulin glargine, or their combination on meal-related glycaemic excursions, insulin and glucagon secretion, and gastric emptying in patients with type 2 diabetes.
Diabetes Obes. Metab. 22, 599-611, 2020.
Schliess, F.
NAFLD/NASH: A ticking bomb not yet defused.
Profil Blog. April 25, 2019
Schliess, F.
A life- and disease course approach to health protection and chronic care.
Open Access Government. ISSN 2516:3817, April 12, 2019.
Schliess, F.
Diabetes: A paradigm case for rewarding innovation in value-based healthcare.
Open Access Government. ISSN 2516-3817, June 19, 2018.
Schliess, F.
Preface: Center for Digital Technology and Management (CDTM) Digital Innovation in Diabetes Care Trend Report 2016.
Schliess, F.
Liver first? Part II: NASH and NAFLD pathogenetic traits.
Profil Blog. December 1, 2016.
Schliess, F.
Liver first? Part I: The liver in diabetes and cardiovascular disease.
Profil Blog. Juli 20, 2016.
Marquard, J., Otter, S., Welters, A., Stirban, A., Eglinger, J., Herebian, D., Kletke, O., Klemen, M.S., Stoze, A., Wnendt, S., Piemonti, L., Köhler, M., Ferrer, J., Thorens, B., Schliess, F., Rupnik, M.S., Heise, T., Berggren, P.O., Klöcker, N., Meissner, T., Mayatepek, E., Eberhard, D., Kragl, M. and Lammert, E.
Characterization of pancreatic N-Methyl-D-Aspartate receptors as possible drug targets for diabetes treatment.
Nature Medicine 21, 363-372, 2015.
Schliess, F.
Open innovation: What’s going on in the healthcare sector?
Profil Blog. October 26, 2015.
Schliess, F.
Diabetic and hepatic encephalopathy: Similarities, synergies and differences.
Profil Blog. July 30., 2015.
Schliess, F.
For healthy living and active ageing: Profil has joined EIT Health.
Profil Blog. April 7, 2015.
Schliess, F., Hoehme, S., Henkel, S.G., Ghallab, A., Driesch, D., Böttger, J., Guthke, R., Pfaff, M., Hengstler, J.G., Gebhardt, R., Häussinger, D., Drasdo, D. and Zellmer, S.
Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration.
Hepatology 60, 2040-2051, 2014.
Karababa, A., Görg, B., Schliess, F. and Häussinger, D.
O-Glc-NAcylation as a novel ammonia-induced post-translational protein modification in cultured astrocytes.
Metab. Brain Dis. 29, 975-982, 2014
Hoffmann, L., Brauers, G., Gehrmann, T., Häussinger, D., Mayatepek, E., Schliess, F. and Schwahn, B.C. Osmotic regulation of hepatic betaine metabolism.
Am. J. Physiol. Gastrointest. Liver Physiol. 304, G835-G846, 2013.
Kruczek, C., Görg, B., Keitel, V., Bidmon, H.J., Schliess, F. and Häussinger, D.
Ammonia increases nitric oxide, free Zn2+ and metallothionein mRNA expression in cultured rat astrocytes.
Biol. Chem. 392, 1155-1165, 2011.
Schliess, F., Görg, B. and Häussinger, D.
RNA oxidation and zinc in hepatic encephalopathy and hyperammonemia.
Metab. Brain Dis. 24, 119-134, 2009.
Kruczek, C., Görg, B., Keitel, V., Pirev, E., Kröncke, K.D., Schliess, F. and Häussinger, D.
Hypoosmotic swelling affects zinc homeostasis in cultured rat astrocytes.
GLIA 57, 79-92, 2009.
Häussinger, D. and Schliess, F.
Pathogenetic mechanisms of hepatic encephalopathy.
Gut 57, 1156-1165, 2008.
Mannack, G., Graf, D., Donner, M.M., Richter, L., Görg, B., vom Dahl, S., Häussinger, D., and Schliess, F.
Taurolithocholic acid-3 sulfate impairs insulin signaling in cultured rat hepatocytes and perfused rat liver.
Cell Physiol. Biochem. 21, 137-150, 2008.
Görg,B., Qvartskhava, N., Keitel, V., Bidmon, H.J., Selbach, O., Schliess, F. and Häussinger, D.
Ammonia induces RNA oxidation in cultured rat astrocytes and brain in vivo.
Hepatology 48, 567-579, 2008.
Schliess, F., Reinehr, R. and Häussinger,
Osmosensing and signaling in the regulation of mammalian cell function.
FEBS J. 274, 5799-5803, 2007.
Häussinger D. and Schliess, F.
Glutamine metabolism and signaling in the liver.
Front. Biosci. 12, 371-391, 2007.
Schliess, F. and Häussinger, D.
Osmosensing by integrins in rat liver.
Meth. Enzymol. 428, 129-144, 2007.
Schäfer, C., Gehrmann, T., Richter, L., Keitel, V., Köhrer, K., Häussinger, D. and Schliess, F.
Modulation of gene expression profiles by hyperosmolarity and insulin.
Cell Physiol. Biochem. 20, 369-386, 2007.
Schäfer, C., Hoffmann, L., Heldt, K., Lornejad-Schäfer, M.R., Brauers, G., Gehrmann, T., Garrow, T.A., Häussinger, D., Mayatepek, E., Schwahn, B. and Schliess, F.
Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells.
Am. J. Physiol Gastrointest. Liver Physiol. 292, G1089-G1098, 2007.
Görg, B., Qvartskhava, N., Voss, P., Grune, T. Häussinger, D., Schliess, F.
Inhibition of mammalian glutamine synthetase by tyrosine nitration.
FEBS Lett. 581, 84-90, 2007.
Häberle, J., Görg, B., Toutain, A., Rutsch, F., Benoist, J.F., Gelot, A., Suc, A.L., Koch, H.G., Schliess, F. and Häussinger, D
Inborn error of amino acid synthesis: human glutamine synthetase deficiency.
J. Inherit. Metab. Dis. 29, 352-358, 2006.
Schliess, F., Görg, B., Reinehr, R., Bidmon, H.J. and Häussinger, D.
Osmotic and oxidative stress in hepatic encephalopathy.
In „Hepatic encephalopathy and nitrogen metabolism“. Editors: D. Häussinger, G. Kircheis, F. Schliess.
Springer, Dordrecht, The Netherlands, p. 20-42.
Schliess, F., Görg, B. and Häussinger, D.
Pathogenetic interplay between osmotic and oxidative stress: The hepatic encephalopathy paradigm.
Biol. Chem. 387, 1363-1370, 2006.
Häussinger, D., Reinehr, R.M. and Schliess, F.
The hepatocyte integrin system and cell volume sensing.
Acta Physiol. 187, 249-255, 2006.
Schliess, F., Richter, L., vom Dahl, S. and Häussinger, D.
Cell hydration and mTOR-dependend signaling.
Acta Physiol. 187, 223-229, 2006.
Häussinger, D., Görg, B., Reinehr, R.M. and Schliess, F.
Protein tyrosine nitration in hyperammonemia and hepatic encephalopathy.
Metab. Brain. Dis. 20, 285-294, 2005.
Schliess, F. and Häussinger, D.
The cellular hydration state: role in apoptosis and proliferation.
Signal Transduction 6, 297-302, 2005.
Lornejad Schäfer, M.R., Schäfer, C., Richter, L., Grune, T., Häussinger, D. and Schliess, F.
Osmotic regulation of MG-132-induced MAP-kinase phosphatase MKP-1 expression in H4IIE rat hepatoma cells.
Cell. Physiol. Biochem. 16, 193-206, 2005.
Lornejad-Schäfer, M.R., Albrecht, U. Poppeck, D., Gehrmann, T., Grune, T., Bode, J.G., Häussinger, D. and Schliess, F.
Osmotic regulation of STAT3 stability in H4IIE rat hepatoma cells.
FEBS Lett. 579, 5791-5707, 2005.
Häberle, J., Görg, B., Rutsch, F., Schmidt, E., Toutain, A., Benoist, J.F., Gelot, A., Suc, A.L., Höhne, W., Schliess, F., Häussinger, D. and Koch, H.G.
Congenital glutamine deficiency with glutamine synthetase mutations.
N. Engl. J. Med. 353, 1926-1933, 2005.
Häussinger, D., Kubitz, R., Reinehr, R.M., Bode, J.G. and Schliess, F.
Molecular aspects of medicine: From experimental to clinical hepatology.
Mol. Aspects Med. 25, 221-360, 2004.
Schliess, F., Foster, N., Görg, B., Reinehr, R. and Häussinger, D.
Hypoosmotic swelling increases protein tyrosine nitration in cultured rat astrocytes.
GLIA 47, 21-29, 2004.
Schliess, F., Reissmann, R., Reinehr, R., vom Dahl, S. and Häussinger, D.
Involvement of integrins and Src in insulin signaling towards autophagic proteolysis in rat liver.
J. Biol. Chem. 279, 21294-21301, 2004.
Häussinger, D., Kurz, A.K., Wettstein, M., Graf, D., vom Dahl, S. and Schliess, F.
Involvement of integrins and Src in tauroursodesoxycholate and swelling-induced choleresis. Gastroenterology 124, 1476-1487, 2003.
Schliess, F. and Häussinger, D.
Cell volume and insulin signalling.
Int. Rev. Cytol. 225, 187-228, 2003.
Schliess,F. and Häussinger D.
The cellular hydration state: a critical determinant for cell death and cytoprotection.
Biol. Chem. 383, 577-583, 2002.
Schliess, F. and Häussinger, D.
Hepatic encephalopathy and nitric oxide.
J. Hepatol. 34, 610-612, 2001.
Schliess, F. and Stoffel, W.
Evolution of the myelin integral membrane proteins of the central nervous system.
Biol. Chem. Hoppe-Seyler 372, 865-874, 1991.